The Clinical Pharmacogenetics Implementation Consortium (CPIC)

June 30, 2015
2:00PM
3:00PM
EST
Fee: 
Free for AMIA members; $50 for non-members
Presenters: 
James M. Hoffman, PharmD, MS, BCPS - Medication Outcomes & Safety Officer, St. Jude Children's Research Hospital

Enabling the Incorporation of Pharmacogenetics into the EHR

Despite substantial scientific progress over the last decade, implementation of pharmacogenetics into clinical practice has been relatively slow. One barrier to implementation of pharmacogenetics is the lack of freely available, peer-reviewed, updatable, and detailed gene/drug clinical practice guidelines. The Clinical Pharmacogenetics Implementation Consortium (CPIC), which is funded by the NIH, was formed in late 2009, as a shared project between PharmGKB (www.PharmGKB.org) and the Pharmacogenomics Research Network (www.pgrn.org). CPIC provides clinical guidelines that enable the translation of genetic laboratory test results into actionable prescribing decisions for specific drugs. CPIC guidelines are developed using established and rigorous methods, and as of May 2015, CPIC has produced 17 guidelines that help clinicians use available genetic test results to optimize drug therapy.

Recognizing the potential to facilitate the adoption of CPIC guidelines into electronic health records with clinical decision support (CDS), a formal working group was established within CPIC in 2013 to facilitate the adoption of the CPIC guidelines by identifying, and resolving where possible, potential technical barriers to the implementation of the guidelines within a clinical electronic environment. CPIC Informatics develops comprehensive translation tables that illustrate how genotype test results can be used to infer molecular phenotype, which is used as the basis for clinical recommendations that can be implemented as clinical decision support within an electronic health record. CPIC is also leading an effort to standardize terms for clinical pharmacogenetic tests.  This webinar will provide an overview of CPIC, illustrate how CPIC guidelines can be used by clinicians to make specific prescribing decisions for patients and show how CPIC guidelines have been essential to successful implementation of pharmacogenetics within a clinical electronic environment with CDS.

You should register for this webinar if you are interested in learning more about the resources available to help implement pharmacogenetics into the EHR with CDS. 

Learning Objectives

After this webinar, learners will be better able to:

  • Describe CPIC and the underlying assumptions of CPIC guidelines
  • Explain the CPIC guideline development process
  • Demonstrate how CPIC guidelines can be used by clinicians to make specific prescribing decisions for patient care when genetic information is available
  • Demonstrate how CPIC guidelines can be used to aid the clinical implementation of pharmacogenomics into the electronic health record with clinical decision support

Speaker Information

James M. Hoffman, PharmD, MS, BCPS
Medication Outcomes & Safety Officer
Associate Member, Pharmaceutical Sciences
St. Jude Children's Research Hospital

Dr. Hoffman is an Associate Member in Pharmaceutical Sciences and the Medication Outcomes and Safety Officer at St. Jude Children’s Research Hospital in Memphis, Tennessee.  Dr. Hoffman leads medication use safety efforts across St. Jude, where patients with catastrophic diseases routinely require complex and high risk medications. His primary interests include patient safety event detection, clinical decision support, and the clinical implementation of pharmacogenetics.

He is an investigator on PG4KDS, which is St. Jude’s effort to implement pre-emptive pharmacogenetics. (www.stjude.org/pg4kds)  Dr. Hoffman has been a member of the Clinical Pharmacogenetic Implementation Consortium (CPIC) since its inception.  In 2013, along with colleagues from the Mayo Clinic and Stanford, he expanded CPIC’s focus on the integration of pharmacogenetics into the electronic health record by forming a formal informatics working group within CPIC.  https://www.pharmgkb.org/page/cpicInformatics.