Monday, April 7, 1:30 p.m. – 3:00 p.m.
TBI Opening Plenary Session
Robert Plenge, MD, PhD
Vice President, Merck Research Laboratories (MRL) and Worldwide Head, Genetics and Pharmacogenomics (GpGx)
Dr. Plenge’s department, which is part of Early Development and Discovery Sciences (EDDS) under the direction of Dr. Rupert Vessey, is responsible for genetics and pharmacogenomics strategy throughout Merck’s entire pipeline – from early discovery to late-stage clinical development. Prior to joining Merck in July 2013, Dr. Plenge served as Director of Genetics & Genomics in the Division of Rheumatology, Immunology and Allergy at Brigham and Women’s Hospital; Assistant Professor of Medicine at Harvard Medical School; and Associate Member of the Broad Institute of MIT and Harvard. His academic research focused on genetic and genomic underpinnings of complex human disease, with attention to immunemediated diseases such rheumatoid arthritis (RA).
Tuesday, April 8, 3:30 p.m. – 5:00 p.m.
TBI Keynote Presentation
Isaac S. Kohane, MD, PhD
Henderson Professor of Pediatrics and Health Sciences and Technology; Co-Director Center for Biomedical Informatics Harvard Medical School; Director of the Francis A. Countway Library of Medicine
Dr. Kohane is a founder of the Center for Outcome and Policy Research at the Dana-Farber Cancer Institute and founder and Associate Director for the Center for Genetic Epidemiology at Harvard Medical School (HMS). He leads multiple collaborations at HMS and is hospital affiliates in the use of genomics and computer science to study cancer and the development of the brain (with emphasis on autism). He has developed several computer systems to allow multiple hospital systems to be used as “living laboratories” to study the genetic basis of disease while preserving patient privacy. Dr. Kohane’s research builds on his doctoral work in computer science on decision-support and subsequent research in machine-learning applied to biomedicine. Dr. Kohane leads several NIH-funded efforts to translate genomic research into clinical practice and continues his own practice in pediatric endocrinology at Boston Children’s Hospital.
Wednesday, April 9, 8:30 a.m. – 10:00 a.m.
CRI Opening Session and Keynote Presentation
Richard Platt, MD, MSc
Professor and Chair of the Department of Population Medicine; Executive Director of the Harvard Pilgrim Health Care Institute
Dr. Platt is a Principal Investigator of the FDA Mini-Sentinel program, which performs post-marketing safety surveillance using the electronic health data from over 125 million people. Dr. Platt is also principal investigator of PCORI's PCORnet coordinating center, a newly established consortium of 29 networks that will use electronic health data to conduct comparative effectiveness research. He co-leads the coordinating center of the NIH Health Care System Research Collaboratory and leads a CDC Prevention Epicenter, and an AHRQ DEcIDE program. Dr. Platt has been Principal investigator of a CDC Center of Excellence in Public Health Informatics, and an AHRQ CERT.
Wednesday, April 9, 3:30 p.m. – 5:00 p.m.
TBI Closing Session: Translational Bioinformatics Year-in-Review
Russ B. Altman, MD, PhD, FACMI
Kenneth Fong Professor of Bioengineering, Genetics, Medicine and (by courtesy) Computer Science; Director, Biomedical Informatics Training Program, Stanford University
Dr. Altman focuses on the creation and application of computational tools to solve problems in biology and medicine. He focuses particularly on the molecular mechanisms of drug action and drug response, integrating data at the molecular, cellular, organism and population levels. He is interested in methodological innovation in informatics, including knowledge representation, machine learning, natural language processing, data mining, and physical simulation.
Friday, April 11, 10:30 a.m. – 12:00 p.m.
CRI Closing Session and Clinical Research Informatics Year-in-Review
Peter J. Embi, MD, MS, FACMI
Associate Professor and Vice Chair, Department of Biomedical Informatics, The Ohio State University; Chief Research Information Officer, The Ohio State University Medical Center; Physician, Department of Internal Medicine, Division of Rheumatology & Immunology
Dr. Embi is an internationally recognized researcher and educator in the field of clinical research informatics, with numerous publications and presentations describing his innovations in the field. Dr. Embi joined the Medical Center in 2010 from the University of Cincinnati Academic Health Center where he was Associate Professor of Clinical Medicine and Director of Biomedical Informatics in the Center for Clinical and Translational Science and Training. He has served as an adjunct assistant professor in Ohio State’s Department of Biomedical Informatics since 2008. He is also the founding director of the Center for Health Informatics at the University of Cincinnati Academic Health Center.