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Summit on Translational Bioinformatics

Papers and Posters

Papers
Papers presented at the Summit on Translational Bioinformatics will showcase the latest progress on using informatics approaches to improve translational biomedical research. Three scientific papers will be featured in each 90 minute session. At the Summit, Authors will have 20 minutes to present their work, along with 10 minutes for questions and discussion. Topics for papers will include:
Papers: Ontologies in Translational Bioinformatics
  • Ontology-anchored Approaches to Conceptual Knowledge Discovery in a Multi-dimensional Research Data Repository, Philip Payne, The Ohio State University, Co lumbus, OH
  • Ontology-driven Indexing of Public Datasets for Translational Bioinformatics, Nigam, Shah, Stanford University, Stanford, CA
  • Ontology Driven Integration Platform for Clinical and Translational Research, Parsa Mirhaji, The University of Texas Health Science Center at Houston, Houston, Texas
Papers: Methods and Workflows
  • Toward Computational Neuroanatomy: A Functional Representation of Neural Components and Connectivity, Daniel Rubin, Stanford University, Stanford, CA
  • Toward the commoditization of translational genomic research: Design and implementation features of the Galaxy meta-application, Ross Lazarus, Harvard University, Boston, MA
  • PSI: The Dutch Academic Infrastructure for shared biobanks for translational research, Jan Talmon, Maastricht University, Maastricht, The Netherlands
Papers: Translational Bioinformatics for Cancer Research
  • An integrative framework for cancer research using multiple genomic technologies, JuHan Kim, Seoul National University, Seoul, Republic of Korea
  • Metadata Mapping and Reuse in caBIGTM, Lewis Frey, University of Utah, Salt Lake City, UT
  • Learning predictive models for multiple heterogeneous proteomic data-sources, Michal Valko, University of Pittsburgh, Pittsburgh, PA
Papers: Representing clinical and molecular knowledge
  • A Diagram Editor for Efficient Biomedical Knowledge Capture and Integration, Fan Meng, University of Michigan, Ann Arbor, MI
  • Evaluation of a gene information summarization system by users during the analysis process of actual research microarray datasets, Jianji Yang, Oregon Health and Science University, Portland, OR
  • A Theory and In Silico Method for Enabling Rational Translational Research, C. Anthony Hunt, University of California, San Francisco, CA
Papers: Linking genes, variants, proteins, and phenotypes
  • Learning Gene-based Bayesian Networks from SNPs Data for Phenotype Forecasting, Alberto Malovini, IRCCS Multimedica, Milano, Italy
  • PhenoGO: A Resource for the Multiscale Integration of Clinical and Biological Data, Lee Sam, University of Michigan, Ann Arbor, MI
  • BioProspecting: Novel Marker Discovery Obtained by Mining the Medical Literature, Peter Elkin, Mayo Clinic, Rochester, MN
Papers: Human phenotypes and phenomics
  • Application of Natural Language Processing to VA Electronic Health Records to Identify Phenotypic Characteristics for Clinical and Research Purposes,, Adi Gundlapalli, University of Utah School of Medicine, Salt Lake City, UT
  • Mining Human Phenome to Investigate Modularity of Complex Disorders, RangaChandra Gudivada, University of Cincinnati, Cincinnati, OH
  • The Human Disease "Etiome", Yueyi Liu, Stanford University, Stanford, CA
Papers: Robust methods (with a cluster on infectious disease)
  • Towards Bioinformatics Assisted Infectious Disease Control, Vitali Sintchenko, Centre for Infectious Diseases and Microbiology, Sydney, New South Wales, Australia
  • Robust Methods for Accurate Diagnosis Using Microbiological Arrays, Yves, Lussier, The University of Chicago, Chicago, IL
  • Tnter-session reproducibility measures for high-throughput data sources, Milos, Hauskrecht, University of Pittsburgh, Pittsburgh, PA
Papers: Extracting knowledge from human epidemiology, pharmacology, and clinical care
  • Pharmspresso: a text analysis tool for linking pharmacogenomic concepts, Yael, Garten, Stanford University, Stanford, CA
  • Construction of Multi-dimensional Arterial Health Status Map based on Molecular and Clinical Measurements, Fuzzy Expert System and Data Cubes, Lawrence, Chan, Hong Kong Polytechnic University, Hong Kong
  • Reverse Translational Bioinformatics: A Bioinformatics Assay Of Age, Gender And Clinical Biomarkers, Eitan, Rubin, Ben Gurion University, Beer Sheva, Israel
Papers: Knowledge-based enablement of genetics
  • Leveraging existing biological knowledge in the identification of candidate genes for facial dysmorphology., Hannah, Tipney, University of Colorado and Health Sciences Center, Aurora, CO
  • Identifying Hypothetical Genetic Influences on Complex Disease phenotypes, Benjamin, Keller, Eastern Michigan University, Ypsilanti, MI
  • GeneRanker: An Online System for Predicting \r\nGene-Disease Associations for Translational Research, Graciela, Gonzalez, Arizona State University, Phoenix, AZ
Posters
Posters are the preferred format for presenting preliminary research results or results of small scale studies, illustrating and discussing innovative systems and services, describing experimental and in-practice projects and programs, reporting experiences with educational programs, and other dimensions of translational bioinformatics. Poster sessions are a component of the summit designed to offer direct access to the authors in a way not possible through podium presentations. The following is a preview of some of the posters that will be presented at the Summit on Translational Bioinformatics.

Track 1: Informatics methods for the analysis of molecular and clinical measurements

NIH National Center for Integrative Biomedical Informatics (NCIBI)
James Cavalcoli, University of Michigan, Ann Arbor, MI

Tight Integration of a Tissue Banking System and Information Warehouse
Selnur Erdal, OSU Medical Center, Columbus, OH

Towards A Translational Healthcare Organization: Creating the Informatics Infrastructure
Rosemary Ferdinand, Deloitte, Caldwell, NJ

Prior knowledge in the inference of cellular networks with dynamic Gaussian networks: results from a simulation study
Fulvia Ferrazzi, University of Pavia, Pavia, Italy

ICU Data Mart: Informatics Infrastructure for Automatics Calculation of Critical Care Prognostic Scores
Vitaly Herasevich, Mayo Clinic, Rochester, MN

A Library-Based Approach to Teaching Translational Informatics
Kristi Holmes, Washington University in St. Louis School of Medicine, St. Louis, MO

NCIBI Portal - Collaborative Biomedical Research Environment
Yuri Ikeda, University of Michigan, Ann Arbor, MI

A Document Clustering and Ranking System for Exploring MEDLINE Citations
Ying Liu, University of Texas at Dallas, Richardson, TX

Development of a critical care data warehouse to support clinical data management and facilitate knowledge discovery
Geoffrey Manley, University of CA, San Francisco, San Francisco, CA

Enterprise-wide authentication and authorization strategies for support of translational research informatics
George Mathew, Fox Chase Cancer Center, Philadelphia, PA

Translating Bioinformatics and Computational Biology in a Biomedical Informatics Graduate Program
Shannon McWeeney, Oregon Health and Sciences University, Portland, OR

Sharing Data Containers in Translational Research
Peter Mork, The MITRE Corp, McLean, VA

Using Latent Class Analysis to Define Disease Phenotypes
Raymond Ownby, University of Miami Miller School of Medicine, Miami Beach, FL

CoMotion: A Visualization Environment for Information Integration
Joe Pedrazzoli, General Dynamics, Pittsburgh, PA

Information Model Unification and Data Management for Medical Data Integration
Christopher Roos, Medicel Oy, Keilaranta, Espoo, Finland

OCRe: The Ontology of Clinical Research
Ida Sim, University of CA, San Francisco, San Francisco, CA

Track 2: Relating and representing phenotypes and disease

CaTER: University of Michigan's Web Portal for Clinical and Translational Empowered Research
Suresh Bhavnani, University of Michigan, Ann Arbor, MI

Semantic Web for Translational Biomedicine: Two Pilot Experiments
Olivier Bodenreider, National Library of Medicine, Bethesda, MD

The BioMed Ontology: Relating Diseases and Pathways
Julie Chabalier, Universite de Rennes, Rennes, France

An Efficient Solution for Mapping Free Text to Ontology Terms
Manhong Dai, University of Michigan, Ann Arbor, MI

Heart failure Origin - Ontology Task - Using ontology development to categorize and analyze clinical data of with nonischemic dilated cardiomyopathy
David Kao, Stanford University, Stanford, CA

Interactive Autism Network (IAN): A Model for Creating an Efficient and Responsive Online Research Infrastructure
Paul Law, Kennedy Krieger Institute, Baltimore, MD

Identifying Text-based Discriminators for Differential Diagnosis of Long QT Syndrome in Children
Long Qu, Childrens Hospital of Philadelphia, Philadelphia, PA

Data Structure and accompanying tools for the dissemination, analysis, storage and integration of Reverse Phase Protein Arrays with clinical and molecular measurements using a novel semantic database S3DB
Romesh Stanislaus, University of Texas, MD Anderson Cancer Center, Houston, TX


Track 3: Dissecting disease through the study of organisms, evolution, and taxonomy

Integration of Clinical, Molecular, and Cellular phenotypes to unravel the mechanisms of complex diseases
Banu Gopalan, Cleveland Clinic, Cleveland, OH

The Bioinformatics System for the Research of
Interleukin 1 Gene Polymorphisms and Related Factors in Gastric Cancers
Kuan-Liang Kuo, Taipei City Hospital, Taiwan, China

Track 4: Computational approaches to finding molecular mechanisms and therapies for disease

Differential renal transcriptional profiles characterize distinct subgroups of patients with Lupus Nephritis
Celine Berthier, University of Michigan, Ann Arbor, MI

Application of a rules based reasoning engine in Clinical Trial management applications
Keith Boyce, ITN/UCSF, Pittsburgh, PA

Toxicoproteomic Analysis of the Effects of Methylazoxymethanol (MAM) on the Neonatal Liver: Potential Serum Biomarkers for Toxicity.
Suzanne Fei, Oregon Health and Sciences University, Portland, OR

Flexibility and Motion Prediction in Proteins
Samuel Flores, Stanford University, Stanford, CA

Generating renal disease outcome predictors in a multidisciplinary international consortium: Using mRNA expression profiles of renal biopsies for prediction of GFR
Anna Henger, University of Michigan, Ann Arbor, MI

A Semantic-Wed Based Method for Abstraction of Drug Resistance Patterns
Genaro Hernandez, Stanford University, Stanford, CA

Interference of globin genes with biomarker discovery for allograft rejection in peripheral blood samples
Li Li, Stanford University, Stanford, CA

Variable Selection of Biomarker, Phenotypic, and Clinical Data with Regression Trees
Marilyn McClelland, North Carolina Central University, Durham, NC

A Knowledge Management Tool for Translational Research
Alberto Riva, University of Florida, Gainesville, FL

Translational Bridge for Personalized Medicine: Biospecimen Information Management
Ethel Rubin, BioFortis, Inc., Columbia, MD

Detecting recurrent DNA copy number alterations from array CGH data with application to follicular lymphoma
Sohrab Shah, University of British Columbia, Vancouver, British Columbia, Canada

SNPit: An Integration Tool for Functional SNP Annotation
Terry Shen, University of Washington, Seattle, WA

An Adaptive Tool for Biomedical Literature Retrieval
David States, University of Michigan, Ann Arbor, MI

Molecular Modeling of Dihydropteroate Synthase (DHPS) of Plasmodiun Falciparum and Virtual Screening, Molecular Dynamics, Designing and Docking studies of the Novel DHPS Inhibitors in Falciparum Malaria
Rajakrishnan Vijayakrishnan, All India Institute of Medical Sciences, New Delhi, , India

Finding significant, shared terms between sets of documents for exploring clusters of biomedical entities
Shirley Wu, Stanford University, Stanford, CA
Summit
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