• The engineering of large-scale domain knowledge, mostly in form of controlled vocabularies, taxonomies, and classification systems. The recent growth of interest in genomics and molecular biology has set another focus on the organization of the fast growing terminological knowledge in this domain.
• Fundamental issues such as the ontological basis, expressiveness, scalability.
• Exploitation of the powers of formal representation.
• Standardization of representation and functionality to increase the applicability of formally represented knowledge.

Other Benefits
AMIA Working Groups serve as a mechanism for members to become involved in a specific area of focus in informatics. Membership in a Working Group avails an individual to assist with projects including:

• White papers
• Programs for the AMIA Annual Symposia
• Separate conferences or meetings devoted to the specific workings of the Working Group
• Position statements
• Members are able to engage in networking activities including:
• Discussion lists
• Business meetings at Annual Symposia